Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Infectious Diseases

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

Early ART vs delayed ART initiation

All‐cause mortality at 6 to 12 months · HIV‐positive people with cryptococcal meningitis

Early ART may leads to higher all‐cause mortality at 6 to 12 months compared with delayed ART initiation (low certainty).

1 finding from 1 review

Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis 2018 · Cochrane Headline outcomes only
RR 1.42 [1.02, 1.97]
4 studies · 294 participants
Low

Early ART vs delayed ART initiation

Cryptococcal meningitis relapse · HIV‐positive people with cryptococcal meningitis

Early ART showed no clear difference in cryptococcal meningitis relapse compared with delayed ART initiation (low certainty).

1 finding from 1 review

Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis 2018 · Cochrane Headline outcomes only
RR 0.27 [0.07, 1.04]
2 studies · 205 participants
Low

Early ART vs delayed ART initiation

Cryptococcal IRIS · HIV‐positive people with cryptococcal meningitis

It is very uncertain whether early ART changes cryptococcal IRIS compared with delayed ART initiation (very low certainty).

1 finding from 1 review

Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis 2018 · Cochrane Headline outcomes only
RR 3.56 [0.51, 25.02]
2 studies · 205 participants
Very low

Early ART vs delayed ART initiation

HIV virological suppression at 6 months (viral load < 400 copies/mL) · HIV‐positive people with cryptococcal meningitis

It is very uncertain whether early ART changes HIV virological suppression at 6 months (viral load < 400 copies/mL) compared with delayed ART initiation (very low certainty).

1 finding from 1 review

Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis 2018 · Cochrane Headline outcomes only
RR 0.93 [0.72, 1.22]
2 studies · 205 participants
Very low