Early showed no clear difference in sampling failure compared with second trimester amniocentesis (moderate certainty).
Early leads to higher laboratory failure compared with second trimester amniocentesis (high certainty).
Early showed no clear difference in known false negative after birth compared with second trimester amniocentesis (moderate certainty).
Early showed no clear difference in known false negative after birth ‐ Incorrect sex determination compared with second trimester amniocentesis (moderate certainty).
The review found no eligible studies for this question.
Early leads to higher anomalies (all recorded) compared with second trimester amniocentesis (high certainty).
Early leads to higher all known pregnancy loss (including termination of pregnancy) compared with second trimester amniocentesis (high certainty).
Early showed no clear difference in spontaneous miscarriage compared with second trimester amniocentesis (moderate certainty).