EDTA vs placebo
All‐cause mortality · atherosclerotic cardiovascular disease
EDTA showed no clear difference in all‐cause mortality compared with placebo (low certainty).
1 finding from 1 review
- RR 0.97 [0.73, 1.28]2 studies · 1792 participantsLow
Findings
What do systematic reviews say?
14 questions · 14 findings · 2 reviews
No studies found 6 · 42.9%GRADE not reported 1 · 7.1%Very low 2 · 14.3%Low 4 · 28.6%Moderate 1 · 7.1%High 0 · 0%
EDTA vs placebo
Coronary heart disease mortality – CHD deaths · atherosclerotic cardiovascular disease
It is very uncertain whether EDTA changes coronary heart disease death compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.02 [0.7, 1.48]1 study · 1708 participantsVery low
EDTA vs placebo
Myocardial infarction · atherosclerotic cardiovascular disease
EDTA showed no clear difference in myocardial infarction compared with placebo (moderate certainty).
1 finding from 1 review
- RR 0.81 [0.57, 1.14]2 studies · 1792 participantsModerate
EDTA vs placebo
Angina · atherosclerotic cardiovascular disease
It is very uncertain whether EDTA changes angina compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.95 [0.55, 1.67]2 studies · 1792 participantsVery low
EDTA vs placebo
Stroke · atherosclerotic cardiovascular disease
EDTA showed no clear difference in stroke compared with placebo (low certainty).
1 finding from 1 review
- RR 0.88 [0.4, 1.92]2 studies · 1867 participantsLow
EDTA vs placebo
Ankle brachial index · atherosclerotic cardiovascular disease
1 finding from 1 review
- no estimate extracted2 studies · 181 participantsLow
EDTA vs placebo
Maximum walking distance · atherosclerotic cardiovascular disease
1 finding from 1 review
- no estimate extracted2 studies · 165 participantsLow
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD
Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD
Adverse effects · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD
Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD
Change in periapical radiolucency (radiography or CBCT), up to 1 year after treatment · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD
Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD
Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesOnly a graph plot of 'average pain' over the 7-day postoperative period in each group was provided; this could not be transformed into usable data for the review's prespecified outcomes.1 studyGRADE not reported
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD
Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found