Findings

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3 questions · 3 findings · 1 reviews · Haematology

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy showed no clear difference in secondary malignant neoplasms compared with ABVD‐like chemotherapy (with or without radiotherapy (low certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
OR 1.37 [0.89, 2.1]
7 studies · 2996 participants
Low

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy showed no clear difference in death compared with ABVD‐like chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
HR 0.85 [0.7, 1.04]
7 studies · 2996 participants
Moderate

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Progression/relapse · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy probably leads to lower progression/relapse compared with ABVD‐like chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
HR 0.82 [0.7, 0.95]
7 studies · 2996 participants
Moderate