Findings

What do systematic reviews say?

6 questions · 8 findings · 1 reviews · Drugs and Alcohol

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 8 · 100%Moderate 0 · 0%High 0 · 0%

Dihydrocodeine vs buprenorphine

Abstinence · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in abstinence Assessed by urinalysis post‐detoxification compared with buprenorphine (low certainty).

3 findings from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
RR 0.42 [0.11, 1.57]
2 studies · 150 participants
Low
Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
RR 0.59 [0.26, 1.31]
2 studies · 150 participants
Low
Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
RR 0.59 [0.25, 1.39]
2 studies · 150 participants
Low

Dihydrocodeine vs buprenorphine

Serious adverse events or adverse events · individuals dependent on illicit opiates

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 150 participants
Low

Dihydrocodeine vs buprenorphine

Treatment retention Early dropout · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in treatment retention Early dropout compared with buprenorphine (low certainty).

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
RR 1.29 [0.99, 1.68]
2 studies · 150 participants
Low

Dihydrocodeine vs methadone

Abstinence · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in abstinence compared with methadone (low certainty).

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 204 participants
Low

Dihydrocodeine vs methadone

Serious adverse events or adverse events Death due to methadone use · individuals dependent on illicit opiates

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 204 participants
Low

Dihydrocodeine vs methadone

Retention in treatment · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in treatment retention compared with methadone (low certainty).

1 finding from 1 review

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders 2020 · Cochrane Headline outcomes only
RR 1.04 [0.94, 1.16]
1 study · 204 participants
Low