Diclofenac vs paracetamol
Outcome№ of participants(studies) · children with acute postoperative pain
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
14 questions · 15 findings · 2 reviews
No studies found 4 · 26.7%GRADE not reported 2 · 13.3%Very low 5 · 33.3%Low 0 · 0%Moderate 0 · 0%High 4 · 26.7%
Diclofenac vs paracetamol
Relief of pain · children with acute postoperative pain
2 findings from 1 review
- no estimate extracted50 participantsGRADE not reported
- no estimate extracted50 participantsGRADE not reported
Diclofenac vs paracetamol
Pain intensity ‐ as reported by child, at 0 to 2 hours № of participants: 180 (2 RCTs) · children with acute postoperative pain
1 finding from 1 review
- no estimate extracted0 studies · 2 participantsVery low
Diclofenac vs paracetamol
Pain intensity ‐ as reported by child, at 2 to 24 hours № of participants: 300 (3 RCTs) · children with acute postoperative pain
1 finding from 1 review
- no estimate extracted2 studies · 3 participantsVery low
Diclofenac vs paracetamol
Nausea and vomiting · children with acute postoperative pain
It is very uncertain whether diclofenac changes nausea, vomiting, or both during study period № of participants: 348… compared with paracetamol (very low certainty).
1 finding from 1 review
- RR 0.47 [0.25, 0.87]5 studies · 348 participantsVery low
Diclofenac vs paracetamol
Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain
It is very uncertain whether diclofenac changes any bleeding during study period № of participants: 332 (5 RCTs) compared with paracetamol (very low certainty).
1 finding from 1 review
- RR 0.57 [0.12, 2.62]5 studies · 332 participantsVery low
Diclofenac vs paracetamol
Serious adverse events during the study period · children with acute postoperative pain
It is very uncertain whether diclofenac changes serious adverse events during study period № of participants: 60 (1… compared with paracetamol (very low certainty).
1 finding from 1 review
- RR 0.5 [0.05, 5.22]1 study · 60 participantsVery low
Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo
Recurrent seizure at 6 months · children with febrile seizures
Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 6 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.8 [0.42, 1.55]1 study · 231 participantsHigh
Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo
Recurrent seizure at 12 months · children with febrile seizures
Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 12 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.69 [0.4, 1.16]1 study · 231 participantsHigh
Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo
Recurrent seizure at 18 months · children with febrile seizures
Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 18 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.72 [0.45, 1.16]1 study · 231 participantsHigh
Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo
Recurrent seizure at 24 months · children with febrile seizures
Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 24 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.79 [0.51, 1.24]1 study · 231 participantsHigh
Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo
Recurrent seizure at 36 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo
Recurrent seizure at 48 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo
Recurrent seizure at 60 months or greater · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found