Findings

What do systematic reviews say?

6 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%

Adverse effect Breakthrough bleeding/spotting · patients with pain associated with endometriosis

Depot progestagen may leads to higher side effects ‐ breakthrough bleeding/spotting compared with other treatment (low certainty).

1 finding from 1 review

Progestagens and anti‐progestagens for pain associated with endometriosis 2012 · Cochrane Headline outcomes only
OR 20.56 [6.44, 65.56]
2 studies · 354 participants
Low

Side effects ‐ bloating · patients with pain associated with endometriosis

It is very uncertain whether depot progestagen changes side effects ‐ bloating compared with other treatment (very low certainty).

1 finding from 1 review

Progestagens and anti‐progestagens for pain associated with endometriosis 2012 · Cochrane Headline outcomes only
OR 4.39 [1.71, 11.3]
1 study · 80 participants
Very low

Local effects at injection site · patients with pain associated with endometriosis

Depot progestagen may leads to higher side effects ‐ injection site reaction compared with other treatment (low certainty).

1 finding from 1 review

Progestagens and anti‐progestagens for pain associated with endometriosis 2012 · Cochrane Headline outcomes only
OR 20.64 [1.19, 358.23]
1 study · 274 participants
Low

Improvement in dysmenorrhoea · patients with pain associated with endometriosis

Depot progestagen may leads to lower improvement in dysmenorrhoea compared with other treatment (low certainty).

2 findings from 1 review

Progestagens and anti‐progestagens for pain associated with endometriosis 2012 · Cochrane Headline outcomes only
OR 0.19 [0.05, 0.69]
1 study · 274 participants
Low
Progestagens and anti‐progestagens for pain associated with endometriosis 2012 · Cochrane Headline outcomes only
OR 0.63 [0.37, 1.08]
1 study · 274 participants
Low

Side effects ‐ hot flushes · patients with pain associated with endometriosis

Depot progestagen may leads to lower side effects ‐ hot flushes compared with other treatment (low certainty).

1 finding from 1 review

Progestagens and anti‐progestagens for pain associated with endometriosis 2012 · Cochrane Headline outcomes only
OR 0.3 [0.11, 0.83]
2 studies · 354 participants
Low

Side effects ‐ amenorrhoea · patients with pain associated with endometriosis

It is very uncertain whether depot progestagen changes side effects ‐ amenorrhoea compared with other treatment (very low certainty).

1 finding from 1 review

Progestagens and anti‐progestagens for pain associated with endometriosis 2012 · Cochrane Headline outcomes only
OR 21.18 [1.18, 380.9]
1 study · 80 participants
Very low