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Evidence found and GRADE certainty

8 questions · 8 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 8 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Bacterial growth inhibition · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry extract inhibits S. mutans growth in vitro (MIC ~0.5-60 mg/mL across 7 studies; ungraded).

1 finding from 1 review

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry extract reduces S. mutans biofilm formation in vitro (10 studies; ungraded).

1 finding from 1 review

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

pH drop / acidogenicity buffering · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry extract reduces S. mutans acidogenicity / glycolytic pH drop in vitro (5 studies; ungraded).

1 finding from 1 review

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry extract alters S. mutans biofilm morphology/architecture (4 studies; ungraded).

1 finding from 1 review

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms)

One study reported antioxidant activity of cranberry polyphenol fractions (ungraded).

1 finding from 1 review

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

GtfB/C and F-ATPase activity · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry proanthocyanidins downregulate GtfB/C and F-ATPase activity of S. mutans (5 studies; ungraded).

1 finding from 1 review

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry extract inhibits S. mutans adhesion / initial colonization in vitro (3 studies; ungraded).

1 finding from 1 review

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Cell death / cytotoxicity induction · Streptococcus mutans (in vitro cultures and biofilms)

One study reported time-dependent cell-death induction (50% at 10 h) with cranberry extract (ungraded).

1 finding from 1 review