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What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 2 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 2 · 16.7%Very low 0 · 0%Low 5 · 41.7%Moderate 2 · 16.7%High 3 · 25%

Corticosteroids (dexamethasone) vs placebo

Number of participants with normal physical joint function ‐ normal function at 12 months of · septic arthritis in children taking antibiotics

Corticosteroids (dexamethasone) may leads to higher number of participants with normal physical joint function ‐ normal… compared with placebo (low certainty).

1 finding from 1 review

Corticosteroids (dexamethasone) vs placebo

Number of days of antibiotic treatment ‐ number of days of intravenous antibiotic treatment · septic arthritis in children taking antibiotics

Corticosteroids (dexamethasone) showed no clear difference in number of days of antibiotic treatment ‐ number of days of… compared with placebo (low certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Mortality Mortality at latest · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) leads to lower mortality at latest reported age compared with control (placebo or nothing) (high certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Bronchopulmonary dysplasia/chronic lung disease · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) probably leads to lower BPD at 36 weeks' PMA compared with control (placebo or nothing) (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) probably leads to lower mortality or BPD at 36 weeks' PMA compared with control (placebo or nothing) (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Cerebral palsy · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) showed no clear difference in cerebral palsy ‐ at latest reported age compared with control (placebo or nothing) (high certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Death or cerebral palsy · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) showed no clear difference in mortality or cerebral palsy ‐ at latest reported age compared with control (placebo or nothing) (high certainty).

1 finding from 1 review