Findings

What do systematic reviews say?

7 questions · 7 findings · 3 reviews · Pregnancy and Childbirth

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 1 · 14.3%Moderate 1 · 14.3%High 1 · 14.3%

Corticosteroids vs promethazine

Severe nausea 17th day · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes severe nausea 17th day compared with promethazine (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.81 [0.58, 1.15]
1 study · 78 participants
Very low

Corticosteroids vs promethazine

Vomiting · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes episodes of vomiting 17th day compared with promethazine (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 1 [0.21, 4.65]
1 study · 78 participants
Very low

Corticosteroids vs promethazine

Intervention side effects: drowsiness 48hrs and 3‐10 days · Pregnant women with hyperemesis gravidarum

Corticosteroids showed no clear difference in intervention side effects: drowsiness 48hrs and 3‐10 days compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.08 [0, 1.32]
1 study · 80 participants
Low

Corticosteroids vs promethazine

Duration of hospital admission (days) · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo

Length of hospital stay · Pregnant women with hyperemesis gravidarum

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 110 participants
Very low

Corticosteroids vs placebo or no treatment

Neonatal death (baby born alive at any gestation and dies within 28 days) · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids leads to lower neonatal death (infants born with signs of life who die within the… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth 2020 · Cochrane Headline outcomes only
RR 0.78 [0.7, 0.87]
Studies not reported
High

Strategies to increase use of antenatal corticosteroids vs usual care

Neonatal death (death within the first 28 days of life) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher neonatal death before 28 days (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.12 [1.02, 1.23]
1 study · 100705 participants
Moderate