Findings

What do systematic reviews say?

7 questions · 7 findings · 2 reviews · Emergency and Critical Care

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 1 · 14.3%High 2 · 28.6%

Corticosteroids vs placebo or usual care

28‐Day all‐cause mortalitya · children and adults with sepsis

Corticosteroids probably leads to lower 28‐Day all‐cause mortalitya compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 0.91 [0.84, 0.99]
50 studies · 11233 participants
Moderate

Corticosteroids vs placebo or usual care

ICU length of stay (general intensive care patients) · children and adults with sepsis

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
no estimate extracted
21 studies · 7612 participants
High

Corticosteroids vs placebo or usual care

Duration of hospital stay MCID: 1 day absolute difference · children and adults with sepsis

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 8795 participants
High

Corticosteroids vs control

Early all‐cause mortality (≤ 3 months) Reported at: day 14; day 28; day 60; and in hospital · adults with acute respiratory distress syndrome

Corticosteroids showed no clear difference in early all‐cause mortality (≤ 3 months) Reported at: day 14; day 28;… compared with control (low certainty).

1 finding from 1 review

Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
RR 0.77 [0.57, 1.05]
6 studies · 574 participants
Low

Corticosteroids vs control

Late all‐cause mortality ( > 3 months · adults with acute respiratory distress syndrome

It is very uncertain whether corticosteroids changes late all‐cause mortality ( > 3 months) Reported at: 180 days compared with control (very low certainty).

1 finding from 1 review

Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
RR 0.99 [0.64, 1.52]
1 study · 180 participants
Very low

Corticosteroids vs control

Duration of mechanical ventilation · adults with acute respiratory distress syndrome

1 finding from 1 review

Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 277 participants
Very low

Corticosteroids vs control

Ventilator‐free days up to day 28 · adults with acute respiratory distress syndrome

1 finding from 1 review

Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 494 participants
Low