Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Acute Respiratory Infections

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Corticosteroids vs no corticosteroid use

All‐cause mortality Up to 28 days following admission · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number of deaths at 30 days following admission (30‐day mortality)a compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Corticosteroids as adjunctive therapy in the treatment of influenza 2019 · Cochrane Headline outcomes only
OR 3.9 [2.31, 6.6]
21 studies · 9536 participants
Very low

Corticosteroids vs no corticosteroid use

Incidence of admissions to the ICU · individuals with influenza

It is very uncertain whether corticosteroid therapy changes rate of admission to intensive care units compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Corticosteroids as adjunctive therapy in the treatment of influenza 2019 · Cochrane Headline outcomes only
OR 5.13 [4.26, 6.17]
1 study · 2141 participants
Very low

Corticosteroids vs no corticosteroid use

Number and nature of adverse events secondary to corticosteroid use (hospital‐acquired infection) · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number and nature of adverse events secondary to corticosteroid use… compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Corticosteroids as adjunctive therapy in the treatment of influenza 2019 · Cochrane Headline outcomes only
OR 2.74 [1.51, 4.95]
7 studies · 6114 participants
Very low

Corticosteroids vs no corticosteroid use

Incidence of mechanical ventilation · individuals with influenza

It is very uncertain whether corticosteroid therapy changes proportion of participants requiring mechanical ventilation compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Corticosteroids as adjunctive therapy in the treatment of influenza 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 4364 participants
Very low