Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Continuous oral valproate vs placebo or no treatment

Recurrent seizure at 6 months · children with febrile seizures

Continuous oral valproate showed no clear difference in recurrent seizure at 6 months compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 1.2 [0.55, 2.62]
2 studies · 156 participants
Low

Continuous oral valproate vs placebo or no treatment

Recurrent seizure at 12 months · children with febrile seizures

Continuous oral valproate showed no clear difference in recurrent seizure at 12 months compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.82 [0.52, 1.29]
4 studies · 255 participants
Low

Continuous oral valproate vs placebo or no treatment

Recurrent seizure at 18 months · children with febrile seizures

It is very uncertain whether continuous oral valproate changes recurrent seizure at 18 months compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.13 [0.02, 0.96]
1 study · 48 participants
Very low

Continuous oral valproate vs placebo or no treatment

Recurrent seizure at 24 months · children with febrile seizures

Continuous oral valproate showed no clear difference in recurrent seizure at 24 months compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 1.26 [0.73, 2.18]
2 studies · 156 participants
Low

Continuous oral valproate vs placebo or no treatment

Recurrent seizure at 36 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous oral valproate vs placebo or no treatment

Recurrent seizure at 48 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous oral valproate vs placebo or no treatment

Recurrent seizure at 60 months or greater · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found