Findings

What do systematic reviews say?

5 questions · 7 findings · 1 reviews · Oral medicine and oral cancer

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No studies found 0 · 0%GRADE not reported 7 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Common genetic variants genome-wide (GWAS; ~3.9 million SNPs with MAF > 5%) vs ECC-unaffected children (per-allele case-control association)

Early childhood caries (ECC) - association at lead SNP rs76823412 (8:134690570; nearest gene(s) ST3GAL1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

The common variant rs8091366 near CHST9, KCTD1 showed suggestive (not genome-wide significant) association with ECC (Z = 4.476, p = 7.60e-6); genetic association, ungraded.

2 findings from 1 review

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies… 2022 All outcomes
Cross-sectional (ECC ascertained at the last dental exam before age 6) · Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only · rs8091366 (18:24715618); effect/non-effect allele A/G; MAF 0.52; direction across 5 cohorts +++++
Z-score (Stouffer's combined Z, 5 cohorts) 4.476
5 studies · 2974 participants
GRADE not reported
Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies… 2022 All outcomes
Cross-sectional (ECC ascertained at the last dental exam before age 6) · Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only · rs76823412 (8:134690570); effect/non-effect allele T/C; MAF 0.47; direction across 5 cohorts +++++
Z-score (Stouffer's combined Z, 5 cohorts) 4.806
5 studies · 2974 participants
GRADE not reported

Common genetic variants genome-wide (GWAS; ~3.9 million SNPs with MAF > 5%) vs ECC-unaffected children (per-allele case-control association)

Early childhood caries (ECC) - association at lead SNP rs563135 (10:115067899; nearest gene(s) TCF7L2, CASP7) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

The common variant rs563135 near TCF7L2, CASP7 showed suggestive (not genome-wide significant) association with ECC (Z = -4.532, p = 5.86e-6); genetic association, ungraded.

1 finding from 1 review

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies… 2022 All outcomes
Cross-sectional (ECC ascertained at the last dental exam before age 6) · Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only · rs563135 (10:115067899); effect/non-effect allele A/C; MAF 0.51; direction across 5 cohorts -----
Z-score (Stouffer's combined Z, 5 cohorts) -4.532
5 studies · 2974 participants
GRADE not reported

Common genetic variants genome-wide (GWAS; ~3.9 million SNPs with MAF > 5%) vs ECC-unaffected children (per-allele case-control association)

Early childhood caries (ECC) - association at lead SNP rs1044956 (7:24854765; nearest gene(s) OSBPL3, NPVF) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

The common variant rs1044956 near OSBPL3, NPVF showed suggestive (not genome-wide significant) association with ECC (Z = 4.551, p = 5.35e-6); genetic association, ungraded.

2 findings from 1 review

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies… 2022 All outcomes
Cross-sectional (ECC ascertained at the last dental exam before age 6) · Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only · rs1044956 (7:24854765); effect/non-effect allele A/G; MAF 0.49; direction across 5 cohorts +++++
Z-score (Stouffer's combined Z, 5 cohorts) 4.551
5 studies · 2974 participants
GRADE not reported
Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies… 2022 All outcomes
Cross-sectional (ECC ascertained at the last dental exam before age 6) · Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only · rs9889096 (16:13575143); effect/non-effect allele T/G; MAF 0.50; direction across 5 cohorts --+--
Z-score (Stouffer's combined Z, 5 cohorts) -4.541
5 studies · 2974 participants
GRADE not reported

Common genetic variants genome-wide (GWAS; ~3.9 million SNPs with MAF > 5%) vs ECC-unaffected children (per-allele case-control association)

Early childhood caries (ECC) - association at lead SNP rs7325099 (13:28104496; nearest gene(s) LNX2, POLR1D, RPL21) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

The common variant rs7325099 near LNX2, POLR1D, RPL21 showed suggestive (not genome-wide significant) association with ECC (Z = 4.485, p = 7.28e-6); genetic association, ungraded.

1 finding from 1 review

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies… 2022 All outcomes
Cross-sectional (ECC ascertained at the last dental exam before age 6) · Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only · rs7325099 (13:28104496); effect/non-effect allele A/C; MAF 0.50; direction across 5 cohorts ++?++
Z-score (Stouffer's combined Z, 5 cohorts) 4.485
5 studies · 2974 participants
GRADE not reported

Common genetic variants genome-wide (GWAS; ~3.9 million SNPs with MAF > 5%) vs ECC-unaffected children (per-allele case-control association)

Early childhood caries (ECC) - association at lead SNP rs74470773 (3:33958083; nearest gene(s) PDCD6IP) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

The common variant rs74470773 near PDCD6IP showed suggestive (not genome-wide significant) association with ECC (Z = -4.589, p = 4.46e-6); genetic association, ungraded.

1 finding from 1 review

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies… 2022 All outcomes
Cross-sectional (ECC ascertained at the last dental exam before age 6) · Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only · rs74470773 (3:33958083); effect/non-effect allele T/C; MAF 0.47; direction across 5 cohorts -----
Z-score (Stouffer's combined Z, 5 cohorts) -4.589
5 studies · 2974 participants
GRADE not reported