Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Hypertension

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Total mortality · people with primary hypertension

It is very uncertain whether combination therapy changes total mortality compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 1.35 [0.08, 21.72]
3 studies · 568 participants
Very low

Cardiovascular mortality · people with primary hypertension

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 568 participants
Very low

Cardiovascular events · people with primary hypertension

It is very uncertain whether combination therapy changes cardiovascular events compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.98 [0.22, 4.41]
3 studies · 568 participants
Very low

Serious adverse events · people with primary hypertension

It is very uncertain whether combination therapy changes serious adverse events compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.77 [0.31, 1.92]
3 studies · 568 participants
Very low

Withdrawals due to adverse events · people with primary hypertension

It is very uncertain whether combination therapy changes withdrawals due to adverse effects compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.85 [0.53, 1.35]
3 studies · 568 participants
Very low