Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 66.7%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Combination therapy vs monotherapy

Serious adverse events · people with primary hypertension

It is very uncertain whether combination therapy changes serious adverse events compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.77 [0.31, 1.92]
3 studies · 568 participants
Very low

Combination vs nicotine replacement therapy monotherapy

Overall serious adverse events · people who smoke

Combination showed no clear difference in overall serious adverse events compared with single‐form nicotine replacement therapy (low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 4.44 [0.76, 25.85]
5 studies · 2888 participants
Low

Combination with potassium‐sparing diuretics vs monotherapy

Serious adverse events · people with primary hypertension

It is very uncertain whether combination with potassium‐sparing diuretics changes serious adverse events compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.72 [0.1, 5.04]
1 study · 200 participants
Very low