Findings

What do systematic reviews say?

14 questions · 14 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 10 · 71.4%Very low 2 · 14.3%Low 2 · 14.3%Moderate 0 · 0%High 0 · 0%

Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Service utilisation outcomes: hospital admission or days in hospital · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day)

Service utilisation outcomes: hospital admission or days in hospital · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day)

Global state: clinically important change in global state · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Functioning: clinically important change in general functioning, as defined by individual studies · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Adverse effect: clinically important adverse effect (weight ‐ BMI) · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 58 participants
Low

Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Service use: time to hospitalisation · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Quality of life: clinically important change in quality of life · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day)

Mental state: clinically important response, as defined by individual studies * · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low

Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day)

Functioning: clinically important change in general functioning, as defined by individual studies · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day)

Adverse effect: clinically important adverse effect (weight ‐ BMI) · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day)

Service use: time to hospitalisation · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day)

Quality of life: clinically important change in quality of life · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Global state: clinically important change in global state · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Mental state: clinically important response, as defined by individual studies * · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low