Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 5 · 71.4%Very low 0 · 0%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%

Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Global state: clinically important change in global state · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Mental state: clinically important response in mental state BPRS score >30% change · patients with schizophrenia

Clozapine: low dose (150 mg/day to 300 mg/day) showed no clear difference in mental state: clinically important response in mental state BPRS… compared with standard dose (301 mg/day to 600 mg/day) (low certainty).

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
RR 0.93 [0.78, 1.1]
1 study · 176 participants
Low

Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Functioning: clinically important change in general functioning, as defined by individual studies · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Adverse effect: clinically important adverse effect (weight ‐ BMI) · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Low

Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Service utilisation outcomes: hospital admission or days in hospital · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Service use: time to hospitalisation · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Quality of life: clinically important change in quality of life · patients with schizophrenia

1 finding from 1 review

Clozapine dose for schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported