Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 1 reviews · Neonatal

No studies found 3 · 21.4%GRADE not reported 0 · 0%Very low 9 · 64.3%Low 2 · 14.3%Moderate 0 · 0%High 0 · 0%

Clonidine and opioid vs opioid

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes treatment failure To discharge compared with opioid alone (very low certainty).

1 finding from 1 review

Clonidine and opioid vs opioid

Mortality after discharge (1‐3 months) · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes mortality post discharge compared with opioid alone (very low certainty).

1 finding from 1 review

Clonidine and opioid vs opioid

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with opioid alone (very low certainty).

1 finding from 1 review