Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Clonidine and opioid vs opioid

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with opioid alone (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 3 [0.13, 71.51]
1 study · 80 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 1.55 [0.44, 5.4]
2 studies · 93 participants
Very low