Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

53 questions · 53 findings · 6 reviews

No studies found 13 · 24.5%GRADE not reported 1 · 1.9%Very low 10 · 18.9%Low 22 · 41.5%Moderate 7 · 13.2%High 0 · 0%

Clonidine and opioid vs opioid

Mortality after discharge (1‐3 months) · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes mortality post discharge compared with opioid alone (very low certainty).

1 finding from 1 review

Clonidine and opioid vs opioid

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with opioid alone (very low certainty).

1 finding from 1 review