Findings

What do systematic reviews say?

64 questions · 80 findings · 9 reviews

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No studies found 26 · 32.5%GRADE not reported 15 · 18.8%Very low 13 · 16.3%Low 15 · 18.8%Moderate 11 · 13.8%High 0 · 0%

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

Analgesic (painkiller) use · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)

Single preoperative dose of systemic antibiotics (clindamycin 600… showed no clear difference in analgesic use compared with matched placebo, total chemo-mechanical debridement and root filling; GRADE not reported.

1 finding from 1 review

Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes
7 days
RR 0.87 [0.48, 1.55]
1 study · 72 participants
GRADE not reported

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

Pain at 72 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)

1 finding from 1 review

Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes
72 hours
The median pain at 72 hours in the control group was 0 (range 0 to 10); the median pain at 72 hours in the intervention group was the same (median 0, range 0 to 7). P = 0.116 (Mann-Whitney U).
1 study · 72 participants
Low

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

Adverse effects · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)

1 finding from 1 review

Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes
7 days
No adverse effects reported in the placebo group; 1 participant reported dizziness in the intervention group. 72 participants (1 study).
1 study · 72 participants
Low

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

Pain at 7 days · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)

1 finding from 1 review

Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes
7 days
The median pain at 7 days in the control group was 0 (range 0 to 3); the median pain at 7 days in the intervention group was the same (median 0, range 0 to 1). P = 0.673 (Mann-Whitney U).
1 study · 72 participants
Low