What do systematic reviews say?

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes early onset GBS disease (sepsis and/or meningitis within the first… compared with placebo or no treatment (very low certainty).

• Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection 2014 · Cochrane Headline outcomes only
  RR 2.32 [0.34, 15.63]
  2 studies · 987 participants
  Very low

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes GBS pneumonia within the first seven days of life compared with placebo or no treatment (very low certainty).

• Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection 2014 · Cochrane Headline outcomes only
  RR 0.35 [0.01, 8.6]
  2 studies · 987 participants
  Very low

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes neonatal colonization with GBS within the first seven days of life compared with placebo or no treatment (very low certainty).

• Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection 2014 · Cochrane Headline outcomes only
  RR 0.64 [0.4, 1.01]
  3 studies · 328 participants
  Very low

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

• Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 190 participants
  GRADE not reported

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes adverse (mild) effects in the mother compared with placebo or no treatment (very low certainty).

• Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection 2014 · Cochrane Headline outcomes only
  RR 8.5 [1.6, 45.28]
  3 studies · 1066 participants
  Very low

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

• Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1066 participants
  GRADE not reported