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Evidence found and GRADE certainty

11 questions · 11 findings · 1 reviews · Headline outcomes only

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No studies found 2 · 18.2%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 27.3%Moderate 5 · 45.5%High 1 · 9.1%

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Bradycardia · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) leads to lower number of children with clinical adverse event: bradycardia compared with dexmedetomidine intranasal (3 μg/kg) (high certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Number of children with clinical adverse event: unsteadiness within 24 h after discharge · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: unsteadiness within… compared with dexmedetomidine intranasal (3 μg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Number of children with clinical adverse event: crying during administration of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to higher number of children with clinical adverse event: crying during… compared with dexmedetomidine intranasal (3 μg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Vomiting · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: vomiting compared with dexmedetomidine intranasal (3 μg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who successfully completed neurodiagnostic procedure without interruption by the child awakening · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who required a further dose of either the same sedative agent or the addition of a different sedative agent · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg or 100 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg or 100 mg/kg) may leads to higher number of children with clinical adverse events (any) compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (low certainty).

1 finding from 1 review