What do systematic reviews say?

Concomitant (concurrent) chemoradiotherapy vs radical surgery

• Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Concomitant (concurrent) chemoradiotherapy vs radical surgery

The review found no eligible studies for this question.

• Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Concomitant (concurrent) chemoradiotherapy vs radical surgery

It is very uncertain whether chemoradiotherapy changes recurrence compared with radical surgery (very low certainty).

• Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
  OR 2.26 [1.24, 4.14]
  1 study · 215 participants
  Very low

Concomitant (concurrent) chemoradiotherapy vs radical surgery

The review found no eligible studies for this question.

• Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Extended‐field chemoradiotherapy vs pelvic chemoradiotherapy

It is very uncertain whether extended‐field chemoradiotherapy changes overall survival compared with pelvic chemoradiotherapy (very low certainty).

• Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
  HR 0.37 [0.14, 0.96]
  1 study · 74 participants
  Very low

Extended‐field chemoradiotherapy vs pelvic chemoradiotherapy

It is very uncertain whether extended‐field chemoradiotherapy changes para‐aortic lymph node recurrence compared with pelvic chemoradiotherapy (very low certainty).

• Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
  RR 0.19 [0.02, 1.54]
  1 study · 74 participants
  Very low

Extended‐field chemoradiotherapy vs pelvic chemoradiotherapy

It is very uncertain whether extended‐field chemoradiotherapy changes progression‐free survival compared with pelvic chemoradiotherapy (very low certainty).

• Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
  HR 0.25 [0.07, 0.87]
  1 study · 74 participants
  Very low

Extended‐field chemoradiotherapy vs pelvic chemoradiotherapy

It is very uncertain whether extended‐field chemoradiotherapy changes acute adverse events compared with pelvic chemoradiotherapy (very low certainty).

• Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
  RR 0.95 [0.2, 4.39]
  1 study · 74 participants
  Very low

Extended‐field chemoradiotherapy vs pelvic chemoradiotherapy

It is very uncertain whether extended‐field chemoradiotherapy changes late adverse events compared with pelvic chemoradiotherapy (very low certainty).

• Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
  RR 0.95 [0.06, 14.59]
  1 study · 74 participants
  Very low

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

It is very uncertain whether hysterectomy (simple or radical) with chemoradiotherapy changes overall survival Median compared with chemoradiotherapy alone (very low certainty).

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 102 participants
  Very low

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

It is very uncertain whether hysterectomy (simple or radical) with chemoradiotherapy changes progression or event‐free survival Median compared with chemoradiotherapy alone (very low certainty).

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 163 participants
  Very low

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

The review found no eligible studies for this question.

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

The review found no eligible studies for this question.

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

Hysterectomy (simple or radical) with chemoradiotherapy showed no clear difference in overall survival Median compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  HR 0.65 [0.35, 1.21]
  1 study · 211 participants
  Low

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

Hysterectomy (simple or radical) with chemoradiotherapy showed no clear difference in progression or event‐free survival Median compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  HR 0.7 [0.31, 1.34]
  1 study · 211 participants
  Low

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

The review found no eligible studies for this question.

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

Hysterectomy (simple or radical) with chemoradiotherapy may leads to higher severe late complications compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).

• Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
  OR 4
  1 study · 211 participants
  Low