What do systematic reviews say?

Concomitant (concurrent) chemoradiotherapy vs radical surgery

It is very uncertain whether chemoradiotherapy changes recurrence compared with radical surgery (very low certainty).

• Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
  OR 2.26 [1.24, 4.14]
  1 study · 215 participants
  Very low

Extended‐field chemoradiotherapy vs pelvic chemoradiotherapy

It is very uncertain whether extended‐field chemoradiotherapy changes para‐aortic lymph node recurrence compared with pelvic chemoradiotherapy (very low certainty).

• Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
  RR 0.19 [0.02, 1.54]
  1 study · 74 participants
  Very low

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Recurrence: outcome not reported in a usable way (Mehanna 2017: nodal recurrence 3 vs 1; distant metastases 21 vs 23).
  1 study
  GRADE not reported

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in locoregional recurrence compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes

  3 years
  HR 1.00 [0.94, 1.06]
  1 study · 564 participants
  Moderate