What do systematic reviews say?

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cetirizine 10 mg/d vs placebo (4‐week intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 84 participants
  Low

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

Cetirizine 0.5 mg/kg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (18‐month intervention) (moderate certainty).

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  RR 0.68 [0.46, 1.01]
  1 study · 795 participants
  Moderate

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 795 participants
  Moderate

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 795 participants
  Moderate

Cetirizine 10 mg/d vs placebo (4‐week intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 84 participants
  Low

Cetirizine 10 mg/d vs placebo (4‐week intervention)

Cetirizine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty).

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  RR 1.11 [0.5, 2.45]
  1 study · 84 participants
  Low

Cetirizine 10 mg/d vs placebo (4‐week intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 84 participants
  Low

Cetirizine 10 mg/d vs placebo (4‐week intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cetirizine 10 to 20 mg vs placebo

Cetirizine 10 to 20 mg may leads to higher complete suppression of urticaria Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 2.72 [1.51, 4.91]
  2 studies · 178 participants
  Low

Cetirizine 10 to 20 mg vs placebo

Cetirizine 10 to 20 mg showed no clear difference in adverse events leading to withdrawal compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 3 [0.68, 13.22]
  3 studies · 389 participants
  Low

Cetirizine 10 mg/d vs hydroxyzine 25 mg

Cetirizine 10 mg showed no clear difference in adverse events leading to withdrawal compared with hydroxyzine 25 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.78 [0.25, 2.45]
  2 studies · 261 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low