Findings

What do systematic reviews say?

27 questions · 27 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 18 · 66.7%Very low 6 · 22.2%Low 3 · 11.1%Moderate 0 · 0%High 0 · 0%

Cephalosporins vs conventional therapy

Death · patients treated for H. influenzae meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 318 participants
GRADE not reported

Cephalosporins vs penicillin

Resolution of symptoms post‐treatment (ITT analysis) · group A streptococcal pharyngitis

Cephalosporins showed no clear difference in resolution of symptoms post‐treatment (ITT analysis) compared with penicillin (low certainty).

1 finding from 1 review

Different antibiotic treatments for group A streptococcal pharyngitis 2023 · Cochrane Headline outcomes only
OR 0.79 [0.55, 1.12]
5 studies · 2018 participants
Low

Cephalosporins vs penicillin

Resolution of symptoms post‐treatment (evaluable participants) · group A streptococcal pharyngitis

It is very uncertain whether cephalosporins changes resolution of symptoms post‐treatment (evaluable participants) compared with penicillin (very low certainty).

1 finding from 1 review

Different antibiotic treatments for group A streptococcal pharyngitis 2023 · Cochrane Headline outcomes only
OR 0.51 [0.27, 0.97]
5 studies · 1660 participants
Very low

Cephalosporins vs penicillin

Relapse · group A streptococcal pharyngitis

Cephalosporins may leads to lower incidence of relapse (evaluable participants) compared with penicillin (low certainty).

1 finding from 1 review

Different antibiotic treatments for group A streptococcal pharyngitis 2023 · Cochrane Headline outcomes only
OR 0.55 [0.3, 0.99]
4 studies · 1386 participants
Low

Cephalosporins vs penicillin

Adverse events (ITT analysis) · group A streptococcal pharyngitis

It is very uncertain whether cephalosporins changes adverse events (ITT analysis) compared with penicillin (very low certainty).

1 finding from 1 review

Different antibiotic treatments for group A streptococcal pharyngitis 2023 · Cochrane Headline outcomes only
OR 0.94 [0.27, 3.25]
3 studies · 1279 participants
Very low

Third generation cephalosporins vs conventional therapy

Death · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 1496 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Death · patients treated for meningococcal meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 477 participants
GRADE not reported

Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries)

Death · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 1301 participants
GRADE not reported

Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries)

Death: high‐income countries · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 510 participants
GRADE not reported

Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries)

Death: Low/middle‐income countries · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 791 participants
GRADE not reported

Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries)

Deafness · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 501 participants
GRADE not reported

Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries)

Deafness: high‐income countries · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 380 participants
GRADE not reported

Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries)

Deafness: low‐income countries · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 121 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Deafness · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 501 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Culture positivity 10 to 48 hours start of treatment · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 442 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Diarrhoea · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 750 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Neutropenia · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 472 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Rash · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 533 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Treatment failure (either death or deafness) · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 1496 participants
GRADE not reported

Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries)

Death · patients treated for S. pneumoniae meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 129 participants
GRADE not reported