Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

MMP-8 expression/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions

For MMP-8, no clear direction of difference between carious and sound dentin was found; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
Due to the conflicting results of the included studies, no effect direction was found so the evidence is very uncertain regarding the MMP-8 presence in carious vs. sound dentin.
2 studies
Very low

MMP-8 expression/activity · Human coronal carious dentin and sound dentin

No effect direction was found for MMP-8 in carious versus sound dentin (very low certainty).

1 finding from 1 review