Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Carbamazepine vs phenytoin

Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenytoin (time to treatment failure) (moderate certainty).

1 finding from 1 review

Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2019 · Cochrane Headline outcomes only
HR 0.83 [0.61, 1.13]
3 studies · 428 participants
Moderate

Carbamazepine vs phenobarbitone

Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine may leads to lower time to treatment failure (any reason related to treatment)… compared with phenobarbitone (low certainty).

1 finding from 1 review

Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 0.66 [0.49, 0.88]
4 studies · 520 participants
Low