Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Calcineurin inhibitors ± steroids vs placebo/no treatment/supportive treatment/steroids

Total remission (complete or partial) at final · primary membranous nephropathy in adults with nephrotic syndrome

Calcineurin inhibitors ± steroids showed no clear difference in total remission at final compared with placebo/no treatment/supportive treatment/steroids (low certainty).

1 finding from 1 review

Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome 2021 · Cochrane Headline outcomes only
RR 1.21 [0.62, 2.38]
5 studies · 206 participants
Low

Calcineurin inhibitors ± steroids vs alkylating agents ± steroids

Total remission (complete or partial) at final · primary membranous nephropathy in adults with nephrotic syndrome

Calcineurin inhibitors ± steroids showed no clear difference in total remission at final compared with alkylating agents ± steroids (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome 2021 · Cochrane Headline outcomes only
RR 1.01 [0.89, 1.15]
10 studies · 529 participants
Moderate