Findings

What do systematic reviews say?

2 questions · 4 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Average enamel surface roughness · Extracted human teeth with early/artificial enamel lesions (in vitro)

In vitro, CPP-ACP markedly reduced enamel surface roughness versus control (SMD -8.21, 95% CI -10.37 to -6.04; ungraded).

1 finding from 1 review

Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot… 2019 All outcomes
24 hours to 28 days · In vitro (extracted human teeth)
SMD -8.21 [-10.37, -6.04]
3 studies · 56 participants
GRADE not reported

Enamel surface microhardness · Extracted human teeth with early/artificial enamel lesions (in vitro)

In vitro, CPP-ACP increased Vickers microhardness versus control (SMD 1.19, 95% CI 0.72 to 1.66; ungraded).

3 findings from 1 review

Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot… 2019 All outcomes
6 hours to 30 days · In vitro (extracted human teeth) · Vickers microhardness
SMD 1.19 [0.72, 1.66]
5 studies · 106 participants
GRADE not reported
Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot… 2019 All outcomes
6 hours to 30 days · In vitro (extracted human teeth)
SMD 2.07 [1.24, 2.89]
8 studies · 170 participants
GRADE not reported
Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot… 2019 All outcomes
5 to 7 days · In vitro (extracted human teeth) · Knoop microhardness
SMD 3.52 [2.68, 4.36]
3 studies · 64 participants
GRADE not reported