Findings

What do systematic reviews say?

2 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

CPP-ACP vs Placebo or no active treatment

Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…

CPP-ACP did not differ significantly from control (SMD -0.18, 95% CI -0.49 to 0.14); certainty of evidence not assessed (no GRADE).

1 finding from 1 review

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomes
RCTs (clinical and in vitro); predominantly children and adolescents; orthodontic and non-orthodontic white spot lesions, early caries lesions, and artificial lesions
SMD -0.18 [-0.49, 0.14]
8 studies
GRADE not reported

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Laser fluorescence (LF) change · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

For occlusal early caries lesions, adding CPP-ACP to fluorides produced significantly greater laser-fluorescence improvement than fluorides alone (favors the combination); not GRADE-rated.

2 findings from 1 review

Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and… 2018 All outcomes
Post-treatment (3-12 weeks) · In vivo clinical trial (human oral cavity; occlusal early caries lesions) · Location of lesions: occlusal surfaces
MD -21.02 [-27.94, -14.10]
3 studies
GRADE not reported
Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and… 2018 All outcomes
Post-treatment (12-24 weeks) · In vivo clinical trial (human oral cavity; smooth-surface early caries lesions) · Location of lesions: smooth surfaces
MD -13.90 [-39.25, 11.46]
4 studies
GRADE not reported