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What do systematic reviews say?

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Evidence found and GRADE certainty

67 questions · 74 findings · 4 reviews

No studies found 14 · 18.9%GRADE not reported 21 · 28.4%Very low 15 · 20.3%Low 11 · 14.9%Moderate 13 · 17.6%High 0 · 0%

Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day)

Mental state: clinically important response in mental state BPRS score >30% change · patients with schizophrenia

Clozapine: low dose (150 mg/day to 300 mg/day) showed no clear difference in mental state: clinically important response in mental state BPRS… compared with standard dose (301 mg/day to 600 mg/day) (low certainty).

1 finding from 1 review