Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

67 questions · 74 findings · 4 reviews

No studies found 14 · 18.9%GRADE not reported 21 · 28.4%Very low 15 · 20.3%Low 11 · 14.9%Moderate 13 · 17.6%High 0 · 0%

CLOZAPINE + RISPERIDONE vs PLACEBO + CLOZAPINE

Mental state: No 20% response (as defined by PANSS/BPRS total change) · patients with schizophrenia

RISPERIDONE + CLOZAPINE showed no clear difference in mental state: no clinically significant response in psychotic… compared with PLACEBO + CLOZAPINE (low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs PLACEBO + CLOZAPINE

Global state: 2. no significant clinical improvement ‐ CGI, short term (up to 12 weeks) · patients with schizophrenia

RISPERIDONE + CLOZAPINE showed no clear difference in global state: no significant clinical improvement ‐ CGI short term compared with PLACEBO + CLOZAPINE (low certainty).

1 finding from 1 review