Bupropion showed no clear difference in bupropion versus placebo All biochemically validated compared with control (low certainty).
Bupropion may leads to higher bupropion versus placebo Biochemical validation (majority) and self… compared with control (low certainty).
Bupropion leads to higher smoking cessation (at least six months of compared with placebo/no pharmacological treatment (high certainty).
Bupropion showed no clear difference in serious adverse events compared with placebo/no pharmacological treatment (moderate certainty).
Bupropion leads to higher dropouts due to treatment compared with placebo/no pharmacological treatment (high certainty).
Bupropion showed no clear difference in biochemically validated smoking cessation at the latest point in… compared with control (low certainty).
Bupropion showed no clear difference in mean birthweight (g) compared with control (low certainty).
The review found no eligible studies for this question.
Bupropion plus varenicline showed no clear difference in smoking cessation (at least six months of compared with varenicline alone (moderate certainty).
Bupropion plus varenicline showed no clear difference in serious adverse events compared with varenicline alone (low certainty).
Bupropion plus varenicline showed no clear difference in dropouts due to treatment compared with varenicline alone (low certainty).
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in smoking cessation (at least six months of compared with NRT alone (low certainty).
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in serious adverse events compared with NRT alone (low certainty).
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in dropouts due to treatment compared with NRT alone (low certainty).