Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 1 · 33.3%High 0 · 0%

Budesonide 9 mg vs steroids

Clinical remission · Patients with active Crohn's disease

Budesonide 9 mg probably leads to lower induction of clinical remission (CDAI < 150) ‐ 8 weeks compared with conventional steroids (moderate certainty).

1 finding from 1 review

Budesonide for induction of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.85 [0.75, 0.97]
8 studies · 750 participants
Moderate

Budesonide 9 mg vs steroids

Withdrawals due to adverse events · Patients with active Crohn's disease

Budesonide 9 mg showed no clear difference in withdrawal due to adverse events compared with conventional steroids (low certainty).

1 finding from 1 review

Budesonide for induction of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.57 [0.18, 1.84]
5 studies · 522 participants
Low

Budesonide 9 mg vs steroids

Withdrawal due to disease worsening · Patients with active Crohn's disease

It is very uncertain whether budesonide 9 mg changes withdrawal due to disease worsening compared with conventional steroids (very low certainty).

1 finding from 1 review

Budesonide for induction of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1 [0.07, 14.55]
1 study · 30 participants
Very low