Participant‐reported improvement in sialorrhea in the short term · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
Botulinum toxin injection showed no clear difference in participant‐reported improvement in sialorrhea in the short term… compared with placebo (low certainty).
1 finding from 1 review
Reduction in the amount of saliva production in the short term using an objective measure · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
1 finding from 1 review
Health‐related quality of life Assessed by: SeiQoL‐DW (higher scores mean better quality of life) · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
1 finding from 1 review
Adverse effects · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
Botulinum toxin injection may leads to lower adverse effects compared with placebo (low certainty).
1 finding from 1 review
Improvement (greater than 50% of time spent) heel‐toe walking Measured by parents' perception of toe walking frequency more than 50% of the time. · children with ITW gait
It is very uncertain whether botulinum toxin plus conservative treatment changes improvement (greater than 50% of time spent) heel‐toe walking… compared with conservative treatment only (very low certainty).
1 finding from 1 review
Active range of motion of the ankle joint · children with ITW gait
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change from baseline in passive ankle dorsiflexion range of movement · children with ITW gait
1 finding from 1 review
Pain · children with ITW gait
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrence of ITW post‐treatment Assessed by improvement in toe walking based on Gait Analysis Classification An increase indicates improvement (an improvement indicated by a change in downgrading of the severe or 3, moderate or 2, and mild or 1 c... · children with ITW gait
1 finding from 1 review
Adverse events · children with ITW gait
It is very uncertain whether botulinum toxin plus conservative treatment changes adverse events compared with conservative treatment only (very low certainty).
1 finding from 1 review