Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Duration of treatment effect · glabellar lines
1 finding from 1 review
- no estimate extracted1 study · 100 participantsModerate
Findings
What do systematic reviews say?
125 questions · 130 findings · 16 reviews
No studies found 25 · 19.2%GRADE not reported 10 · 7.7%Very low 28 · 21.5%Low 29 · 22.3%Moderate 27 · 20.8%High 11 · 8.5%
Summary of Findings Table ‐ OnabotulinumtoxinA 20U vs placebo
Major adverse events · glabellar lines
Summary of Findings Table ‐ OnabotulinumtoxinA 20U probably leads to higher major adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- OR 3.62 [1.5, 8.74]8 studies · 1390 participantsModerate
Summary of Findings Table ‐ OnabotulinumtoxinA 20U vs placebo
Physician assessment of success · glabellar lines
Summary of Findings Table ‐ OnabotulinumtoxinA 20U probably leads to higher physician assessment of success compared with placebo (moderate certainty).
1 finding from 1 review
- RR 17.1 [10.07, 29.05]7 studies · 1339 participantsModerate
Summary of Findings Table ‐ OnabotulinumtoxinA 20U vs placebo
Total adverse events · glabellar lines
Summary of Findings Table ‐ OnabotulinumtoxinA 20U showed no clear difference in total adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 1.14 [0.89, 1.45]8 studies · 1388 participantsLow
Summary of Findings Table ‐ OnabotulinumtoxinA 20U vs placebo
Duration of treatment effect · glabellar lines
1 finding from 1 review
- no estimate extracted1 study · 77 participantsModerate
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Participant assessment of success by analysing scores and scales ‐ 20 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U leads to higher participant assessment of success by analysing scores and scales ‐… compared with placebo (high certainty).
1 finding from 1 review
- RR 5.33 [1.67, 16.99]1 study · 300 participantsHigh
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Major adverse events (eyelid ptosis, eyelid sensory disorder, strabismus) · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in major adverse events (eyelid ptosis, eyelid sensory disorder,… compared with placebo (moderate certainty).
1 finding from 1 review
- RR 3.36 [0.88, 12.87]7 studies · 1294 participantsModerate
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Physician assessment of success · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U probably leads to higher physician assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).
1 finding from 1 review
- RR 15.78 [8.75, 28.45]7 studies · 1060 participantsModerate
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Total adverse events · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U may leads to higher total adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 1.25 [1.05, 1.49]8 studies · 1471 participantsLow
Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo
Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines
Summary of Findings Table ‐ IncobotulinumtoxinA 20U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).
1 finding from 1 review
- RR 66.57 [13.5, 328.28]2 studies · 547 participantsModerate
Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo
Major adverse events · glabellar lines
1 finding from 1 review
- no estimate extracted2 studies · 547 participantsModerate
Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo
Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines
Summary of Findings Table ‐ IncobotulinumtoxinA 20U probably leads to higher physician assessment of success by analysing scores and scales compared with placebo (moderate certainty).
1 finding from 1 review
- RR 134.62 [19.05, 951.45]2 studies · 547 participantsModerate
Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo
Total adverse events · glabellar lines
Summary of Findings Table ‐ IncobotulinumtoxinA 20U showed no clear difference in total adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 1.17 [0.9, 1.53]2 studies · 547 participantsLow
Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo
Duration of treatment effect ‐ not measured · glabellar lines
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo
Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).
1 finding from 1 review
- RR 21.1 [11.31, 39.34]2 studies · 683 participantsModerate
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo
Major adverse events · glabellar lines
1 finding from 1 review
- no estimate extracted2 studies · 716 participantsModerate
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo
Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher physician assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).
1 finding from 1 review
- RR 23.4 [12.56, 43.61]2 studies · 683 participantsModerate
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo
Total adverse events · glabellar lines
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher total adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- RR 2.23 [1.46, 3.4]2 studies · 716 participantsModerate
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo
Duration of treatment effect · glabellar lines
1 finding from 1 review
- no estimate extracted1 study · 74 participantsModerate
Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)
Salivary Lactobacilli counts · Patients with drooling (sialorrhea) due to neurological disease
Salivary Lactobacilli counts were unchanged in two studies but significantly increased in one study one month after BoNT (ungraded; no effect estimate reported).
1 finding from 1 review
- Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomesBefore vs after BoNT injection (2018 study: significant Lactobacilli increase at 1 month; Wu 2011 and 2017 study no change) · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical careNo statistically significant changes in Lactobacilli CFU counts were reported by Wu et al. or by Tiigimae-Saar 2017. However, the 2018 study found that Lactobacilli CFU counts were significantly increased one month…3 studiesGRADE not reported