Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 2 reviews · Headline outcomes only

No studies found 2 · 18.2%GRADE not reported 0 · 0%Very low 2 · 18.2%Low 5 · 45.5%Moderate 2 · 18.2%High 0 · 0%

Biologics vs placebo

Clinical improvement (dichotomous) · active EoE patients

Biologics showed no clear difference in clinical improvement (dichotomous) compared with placebo (low certainty).

1 finding from 1 review

Biologics vs placebo

Histological improvement (dichotomous) · active EoE patients

Biologics probably leads to higher histological improvement (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review

Biologics vs placebo

Withdrawals due to adverse events · active EoE patients

Biologics showed no clear difference in withdrawals due to adverse events 12 to 44 weeks compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Subcutaneous biologics (dupilumab) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Subcutaneous biologics (dupilumab) showed no clear difference in short‐term hair regrowth ≥ 75% compared with placebo (low certainty).

1 finding from 1 review