Injectional betamethasone vs Normal saline
Treatment‐related adverse effects (long‐term) · men with Peyronie's disease (not defined)
1 finding from 1 review
- no estimate extracted1 study · 30 participantsVery low
Findings
What do systematic reviews say?
50 questions · 50 findings · 9 reviews
No studies found 11 · 22%GRADE not reported 14 · 28%Very low 18 · 36%Low 5 · 10%Moderate 2 · 4%High 0 · 0%
Injectional betamethasone vs Normal saline
Degree of penile curvature · men with Peyronie's disease (not defined)
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Injectional betamethasone vs Normal saline
Treatment discontinuation · men with Peyronie's disease (not defined)
1 finding from 1 review
- no estimate extracted1 study · 30 participantsVery low
Intralesional betamethasone vs placebo
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
- Goel 2015 (3-arm: intralesional betamethasone vs lycopene vs placebo, 90 per arm): appeared to show increased interincisal distance in both intervention groups vs placebo, but only between-group differences with no…1 study · 180 participantsGRADE not reported
Intralesional betamethasone vs intralesional injections of triamcinolone acetonide
Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Intralesional betamethasone may leads to higher clinical resolution compared with intralesional triamcinolone acetonide (low certainty).
1 finding from 1 review
- Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomesRR 1.40 [1.06, 1.83]1 study · 59 participantsLow
Intralesional betamethasone vs intralesional injections of triamcinolone acetonide
Clinical score (14 days) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
It is very uncertain whether intralesional betamethasone changes clinical score (14 days) compared with intralesional triamcinolone acetonide (very low certainty).
1 finding from 1 review
- Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes14 daysMD 9.77 [0.81, 18.73]1 study · 59 participantsVery low
Intralesional betamethasone vs intralesional injections of triamcinolone acetonide
Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Intralesional betamethasone showed no clear difference in pain (mean score) compared with intralesional triamcinolone acetonide (low certainty).
1 finding from 1 review
- Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomesMD -0.41 [-1.47, 0.65]1 study · 59 participantsLow
Systemic (oral) betamethasone vs Topical triamcinolone acetonide paste
Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
It is very uncertain whether systemic (oral) betamethasone changes clinical score compared with topical triamcinolone acetonide paste (very low certainty).
1 finding from 1 review
- Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomesMD 1.13 [0.09, 2.17]1 study · 46 participantsVery low
Systemic (oral) betamethasone vs Topical triamcinolone acetonide paste
Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
It is very uncertain whether systemic (oral) betamethasone changes pain resolution compared with topical triamcinolone acetonide paste (very low certainty).
1 finding from 1 review
- Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomesRR 1.04 [0.60, 1.80]1 study · 49 participantsVery low
Topical betamethasone 0.1% gel vs pimecrolimus 1%
Pain / clinical response (not analysable) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review
- Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomesEzzatt 2019 (betamethasone 0.1% gel vs pimecrolimus 1% gel): effectiveness data not reported in a way that allowed quantitative analysis1 studyGRADE not reported
Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste
Side effects · People with erosive oral lichen planus
1 finding from 1 review
- Table 3 (Side-effects). Malhotra 2008: betamethasone oral mini-pulse - transient oedema over the face (7), oedema over hands and feet (4), epigastric discomfort (7), weakness/fatigue (5), loose stools (1), headache…1 study · 22 participantsGRADE not reported
Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste
Investigator‐ or physician‐rated global assessment of disease severity · People with erosive oral lichen planus
Betamethasone oral mini-pulse therapy led to higher physician Global Assessment (clinical severity, 0-12 score) compared with topical triamcinolone acetonide 0.1% paste; GRADE not reported.
1 finding from 1 review
- Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes24 weeksMD 1.78 [0.17, 3.39]1 study · 22 participantsGRADE not reported
Betamethasone (systemic corticosteroid) vs Placebo or no treatment
Outcome not reported · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
The review found no eligible studies for this question.
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomesTable 1 (Systemic agents used in the management of aphthous stomatitis): 'Studies of these corticosteroids were not found or included in the review but are included here for completeness. They are not given orally for…0 studiesNo studies found
Lycopene plus intralesional betamethasone vs placebo
Severity of oral/mucosal burning pain/sensation · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
- Kumar 2007 reported burning sensation using a non-validated scale; not included in quantitative analysis.1 studyGRADE not reported
Lycopene plus intralesional betamethasone vs placebo
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
- Kumar 2007 (3-arm: lycopene vs lycopene+intralesional betamethasone vs placebo): appeared to show increased interincisal distance in the two active groups, but limited withdrawal information/incomplete data meant…1 studyGRADE not reported
Betamethasone vs usual care
Respiratory distress syndrome · women undergoing planned elective caesarean section at 37 weeks' gestation and beyond for singleton pregnancy
Effect of antenatal corticosteroids (betamethasone) showed no clear difference in respiratory distress syndrome (RDS) compared with usual care prior to planned caesarean at term on maternal and… (low certainty).
1 finding from 1 review
- Antenatal corticosteroids prior to planned caesarean at term for improving neonatal outcomes 2021 · Cochrane Headline outcomes onlyRR 0.34 [0.07, 1.65]1 study · 942 participantsLow
Betamethasone vs usual care
Transient tachypnoea of the neonate (TTN) · women undergoing planned elective caesarean section at 37 weeks' gestation and beyond for singleton pregnancy
Effect of antenatal corticosteroids (betamethasone) showed no clear difference in transient tachypnoea of the neonate (TTN) compared with usual care prior to planned caesarean at term on maternal and… (low certainty).
1 finding from 1 review
- Antenatal corticosteroids prior to planned caesarean at term for improving neonatal outcomes 2021 · Cochrane Headline outcomes onlyRR 0.52 [0.25, 1.11]1 study · 942 participantsLow
Betamethasone vs usual care
Admission to neonatal special care (all levels) for respiratory morbidity · women undergoing planned elective caesarean section at 37 weeks' gestation and beyond for singleton pregnancy
Effect of antenatal corticosteroids (betamethasone) probably leads to lower admission to neonatal special care (all levels) for respiratory… compared with usual care prior to planned caesarean at term on maternal and… (moderate certainty).
1 finding from 1 review
- Antenatal corticosteroids prior to planned caesarean at term for improving neonatal outcomes 2021 · Cochrane Headline outcomes onlyRR 0.45 [0.22, 0.9]1 study · 942 participantsModerate
Betamethasone vs usual care
Need for mechanical ventilation · women undergoing planned elective caesarean section at 37 weeks' gestation and beyond for singleton pregnancy
It is very uncertain whether effect of antenatal corticosteroids (betamethasone) changes need for mechanical ventilation compared with usual care prior to planned caesarean at term on maternal and… (very low certainty).
1 finding from 1 review
- Antenatal corticosteroids prior to planned caesarean at term for improving neonatal outcomes 2021 · Cochrane Headline outcomes onlyRR 4.07 [0.46, 36.27]1 study · 942 participantsVery low
Betamethasone vs usual care
Neonatal hypoglycaemia · women undergoing planned elective caesarean section at 37 weeks' gestation and beyond for singleton pregnancy
1 finding from 1 review
- Antenatal corticosteroids prior to planned caesarean at term for improving neonatal outcomes 2021 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported