What do systematic reviews say?

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers showed no clear difference in total mortality compared with renin‐angiotensin system inhibitors (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.1 [0.98, 1.24]
  3 studies · 10828 participants
  Moderate

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers showed no clear difference in total cardiovascular disease compared with renin‐angiotensin system inhibitors (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1 [0.72, 1.38]
  3 studies · 10828 participants
  Low

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers probably leads to higher total stroke compared with renin‐angiotensin system inhibitors (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.3 [1.11, 1.53]
  2 studies · 9951 participants
  Moderate

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers showed no clear difference in total coronary heart disease compared with renin‐angiotensin system inhibitors (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 0.9 [0.76, 1.06]
  2 studies · 9951 participants
  Low

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers probably leads to higher withdrawal due to adverse effect compared with renin‐angiotensin system inhibitors (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.41 [1.29, 1.54]
  2 studies · 9951 participants
  Moderate

Beta‐blockers vs placebo or no treatment

Beta‐blockers may leads to lower cardiovascular mortality (RR) compared with placebo or no treatment (low certainty).

• Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved… 2021 · Cochrane Headline outcomes only
  RR 0.78 [0.62, 0.99]
  3 studies · 1046 participants
  Low

Beta‐blockers vs placebo or no treatment

It is very uncertain whether beta‐blockers changes heart failure hospitalisation (RR) compared with placebo or no treatment (very low certainty).

• Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved… 2021 · Cochrane Headline outcomes only
  RR 0.73 [0.47, 1.13]
  4 studies · 449 participants
  Very low

Beta‐blockers vs placebo or no treatment

• Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 245 participants
  Very low

Beta‐blockers vs placebo or no treatment

Beta‐blockers showed no clear difference in all‐cause mortality (RR) compared with placebo or no treatment (low certainty).

• Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved… 2021 · Cochrane Headline outcomes only
  RR 0.82 [0.67, 1]
  4 studies · 1105 participants
  Low

Beta‐blockers vs placebo or no treatment

• Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 93 participants
  Very low