Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 1 reviews · Schizophrenia

No studies found 0 · 0%GRADE not reported 8 · 66.7%Very low 4 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

BENZODIAZEPINES + ANTIPSYCHOTICS vs ANTIHISTAMINES + ANTIPSYCHOTICS

Tranquillisation or asleep: sedation ‐ medium termNumber of participants sedated · psychosis‐induced aggression or agitation

It is very uncertain whether benzodiazepines plus antipsychotics changes tranquillisation or asleep: sedation ‐ medium termNumber of… compared with antihistamines plus antipsychotics (very low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs ANTIHISTAMINES + ANTIPSYCHOTICS

Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation

It is very uncertain whether benzodiazepines plus antipsychotics changes global state: no improvement ‐ medium termAs defined in each study compared with antihistamines plus antipsychotics (very low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs ANTIHISTAMINES + ANTIPSYCHOTICS

Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · psychosis‐induced aggression or agitation

It is very uncertain whether benzodiazepines plus antipsychotics changes adverse effects/events: extrapyramidal symptoms ‐ medium termNumber… compared with antihistamines plus antipsychotics (very low certainty).

1 finding from 1 review