What do systematic reviews say?

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Benzodiazepines + antipsychotics showed no clear difference in tranquillisation or asleep: sedation ‐ medium term‐ + haloperidol ‐… compared with same enzodiazepines (low certainty).

• Benzodiazepines for psychosis‐induced aggression or agitation 2017 · Cochrane Headline outcomes only
  RR 0.84 [0.59, 1.19]
  2 studies · 110 participants
  Low

BENZODIAZEPINES + ANTIPSYCHOTICS vs SAME ANTIPSYCHOTICS

It is very uncertain whether benzodiazepines + antipsychotics changes tranquillisation or asleep: sedation ‐ medium term ‐ +/vs… compared with same antipsychotics (very low certainty).

• Benzodiazepines for psychosis‐induced aggression or agitation 2017 · Cochrane Headline outcomes only
  RR 1.75 [1.14, 2.67]
  3 studies · 172 participants
  Very low

BENZODIAZEPINES + ANTIPSYCHOTICS vs ANTIPSYCHOTIC + ANTIPSYCHOTIC

• Benzodiazepines for psychosis‐induced aggression or agitation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

BENZODIAZEPINES + ANTIPSYCHOTICS vs ANTIHISTAMINES + ANTIPSYCHOTICS

It is very uncertain whether benzodiazepines plus antipsychotics changes tranquillisation or asleep: sedation ‐ medium termNumber of… compared with antihistamines plus antipsychotics (very low certainty).

• Benzodiazepines for psychosis‐induced aggression or agitation 2017 · Cochrane Headline outcomes only
  RR 12 [1.66, 86.59]
  1 study · 60 participants
  Very low

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS may leads to higher desired sedation ‐ ultra short term ‐ tranquillised at 60 minutes compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (low certainty).

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  RR 1.39 [1.06, 1.83]
  1 study · 45 participants
  Low

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS showed no clear difference in desired sedation ‐ ultra short term ‐ asleep at 12 hours compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (low certainty).

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  RR 0.85 [0.51, 1.41]
  1 study · 67 participants
  Low