Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

114 questions · 118 findings · 8 reviews

No studies found 14 · 11.9%GRADE not reported 20 · 16.9%Very low 48 · 40.7%Low 33 · 28%Moderate 3 · 2.5%High 0 · 0%

Benzodiazepines vs antipsychotics

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to any reason (overall acceptability of… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to adverse effects (overall tolerability… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global state: no improvement ‐ + haloperidol ‐ medium term As defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ + haloperidol ‐ medium term As… compared with same enzodiazepines (low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ lorazepam + risperidone vs lorazepam… compared with same enzodiazepines (low certainty).

1 finding from 1 review