Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 5 · 62.5%Moderate 2 · 25%High 0 · 0%

Balanced crystalloid solutions vs Normal saline

Time in hospital(days) · children with severe dehydration due to diarrhoea

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Balanced crystalloid solutions vs Normal saline

Mortality (during hospitalization) · children with severe dehydration due to diarrhoea

It is very uncertain whether balanced crystalloid solutions changes mortality (during hospitalization) compared with 0.9% saline (very low certainty).

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
RR 0.33 [0.02, 7.39]
Studies not reported
Very low

Balanced crystalloid solutions vs Normal saline

Need for additional fluids · children with severe dehydration due to diarrhoea

Balanced crystalloid solutions showed no clear difference in need for additional fluids compared with 0.9% saline (low certainty).

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
RR 0.67 [0.26, 1.72]
Studies not reported
Low

Balanced crystalloid solutions vs Normal saline

Total amount of fluids received · children with severe dehydration due to diarrhoea

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Balanced crystalloid solutions vs Normal saline

Final pH after correction (corrected pH) · children with severe dehydration due to diarrhoea

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Balanced crystalloid solutions vs Normal saline

Final bicarbonate level after correction · children with severe dehydration due to diarrhoea

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Balanced crystalloid solutions vs Normal saline

Adverse events: hyponatraemia · children with severe dehydration due to diarrhoea

Balanced crystalloid solutions showed no clear difference in adverse events: hyponatraemia compared with 0.9% saline (low certainty).

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
RR 1.41 [0.96, 2.07]
Studies not reported
Low

Balanced crystalloid solutions vs Normal saline

Adverse events ‐ hypokalaemia · children with severe dehydration due to diarrhoea

Balanced crystalloid solutions probably leads to lower adverse events: hypokalaemia compared with 0.9% saline (moderate certainty).

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
RR 0.54 [0.31, 0.96]
Studies not reported
Moderate