Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 0 · 0%High 1 · 50%

Total failure: day 42 (PCR‐adjusted) · children and adults

Atovaquone‐proguanil showed no clear difference in total failure day 42 PCR‐adjusted compared with artesunate‐mefloquine (high certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 1.15 [0.57, 2.34]
2 studies · 1168 participants
High

Total failure day 42 PCR‐unadjusted · children and adults

Atovaquone‐proguanil showed no clear difference in total failure day 42 PCR‐unadjusted compared with artesunate‐mefloquine (low certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 0.8 [0.5, 1.3]
1 study · 1063 participants
Low