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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 7 findings · 3 reviews

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 0 · 0%Moderate 1 · 14.3%High 1 · 14.3%

Aspirin vs placebo

Major bleedinga · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin leads to higher major bleedinga compared with placebo (high certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Major bleeding · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to higher major bleeding compared with aspirin alone (moderate certainty).

1 finding from 1 review

Aspirin vs low molecular weight heparin

Major bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes major bleeding compared with low molecular weight heparin (LMWH) (very low certainty).

2 findings from 1 review

Aspirin vs vitamin K antagonist (VKA)

Major bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes major bleeding compared with vitamin K antagonist (VKA) (very low certainty).

2 findings from 1 review