Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Intraventricular haemorrhage · very preterm infants at risk of intraventricular hemorrhage

Antithrombin showed no clear difference in intraventricular hemorrhage (any severity, grade 1 to 4) compared with placebo (low certainty).

1 finding from 1 review

Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants 2016 · Cochrane Headline outcomes only
RR 1.3 [0.87, 1.93]
2 studies · 175 participants
Low

Severe intraventricular haemorrhage · very preterm infants at risk of intraventricular hemorrhage

Antithrombin showed no clear difference in severe Intraventricular hemorrhage (grade 3 to 4) compared with placebo (low certainty).

1 finding from 1 review

Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants 2016 · Cochrane Headline outcomes only
RR 1.04 [0.55, 1.94]
2 studies · 175 participants
Low

Neonatal mortality · very preterm infants at risk of intraventricular hemorrhage

It is very uncertain whether antithrombin changes neonatal mortality (all‐cause, < 28 days of age) compared with placebo (very low certainty).

1 finding from 1 review

Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants 2016 · Cochrane Headline outcomes only
RR 2 [0.62, 6.45]
2 studies · 182 participants
Very low