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Evidence found and GRADE certainty

149 questions · 150 findings · 20 reviews

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No studies found 12 · 8%GRADE not reported 18 · 12%Very low 60 · 40%Low 43 · 28.7%Moderate 12 · 8%High 5 · 3.3%

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global impression ‐ need for additional medication ‐ medium term Number of participants requiring additional medication · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: need for additional medication ‐ + haloperidol ‐… compared with same enzodiazepines (low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in adverse effects/events: extrapyramidal symptoms ‐ + haloperidol ‐… compared with same enzodiazepines (low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs no specific treatment

Global state ‐ number of participants with relapse/exacerbations of psychosis (separated time points) ‐ > 1 year · schizophrenia

Summary of findings table ‐ CBT without antipsychotics showed no clear difference in global state ‐ number of participants with relapse/exacerbations of… compared with no specific treatment (low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs no specific treatment

Leaving the study early/ loss to · schizophrenia

Summary of findings table ‐ CBT without antipsychotics showed no clear difference in leaving the study early ‐ for any reason ‐ overall acceptability… compared with no specific treatment (low certainty).

1 finding from 1 review